Horiuchi K, Onyike AE, Osterhout ML. Sickling in vitro of reticulocytes from patients with sickle cell disease at venous oxygen tension. Exp Hematol 1996; 24:68. Onyike AE, Ohene-Frempong K, Horiuchi K. Sickling in vitro at venous and arterial oxygen tensions of reticulocytes from patients with sickle cell disease.

Sickle cell disease (SCD) is a group of inherited red blood cell disorders. Red blood cells contain hemoglobin, a protein that carries oxygen. Healthy red blood cells are round, and they move through small blood vessels to carry oxygen to all parts of the body. In someone who has SCD, the hemoglobin is abnormal, which causes the red blood cells.