Sitagliptin

What is metformin and sitagliptin? Metformin works by decreasing Metformin and sitagliptin is a combination medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 Metformin and sitagliptin may also be used for purposes not listed in this medication guide. Before taking this medicine You should not use metformin and sitagliptin if you are allergic to metformin or sitagliptin ( Tell your doctor if you have ever had: • kidney disease (your kidney function may need to be checked before and while you are taking this medicine); • liver disease; • heart disease; • • • • You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe If you need to have Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. This medicine is not approved for use by anyone younger than 18 years old. How should I take metformin and sitagliptin? Follow all directions on your prescription label and read all medication guides or instruction ...

Brand Name Generic Name Manufacturer Route Formulation Dosage Januvia sitagliptin Merck oral tablet 25 mg, 50mg, 100mg Onglyza saxagliptin Bristol-Myers Squibb oral tablet 2.5 mg, 5mg Tradjenta linagliptin Eli Lilly oral tablet 5 mg Nesina alogliptin Takeda oral tablet 6.25 mg, 12.5 mg, 25 mg Janumet sitagliptin + Merck Sharp & Dohme Corp. oral tablet 50/500 mg, 50/1000 mg Kombiglyze XR saxagliptin + metformin XR Astrazeneca oral tablet 2.5/1000 mg, 5/500 mg, 5/1000 mg Jentadueto linagliptin + metformin Boehringer Ingelheim oral tablet 2.5/500 mg, 2.5/850 mg, 2.5/1000 mg Jentadueto XR linagliptin + metformin XR Boehringer Ingelheim oral tablet 2.5/1000 mg, 5/1000 mg Kazano alogliptin + metformin hydrochloride Takeda oral tablet 12.5/500 mg, 12.5/1000 mg Oseni alogliptin + pioglitazone Takeda oral tablet 25/15 mg, 25/30 mg, 25/45 mg, 12.5/15 mg, 12.5/30 mg, 12.5/45 mg Qtern dapagliflozin + saxagliptin Astrazeneca oral tablet 10/5mg Glyxambi empagliflozin + linagliptin Boehringer Ingelheim oral tablet 10/5 mg, 25/5 mg Steglujan ertugliflozin + sitagliptin Merck oral tablet 5/100 mg, 15/100 mg There are no generic DPP-IV inhibitors availabile on the martket at this time. Patient Assistant Programs: USUAL ADULT DOSING USUAL ADULT DOSING USUAL ADULT DOSING • Sitagliptin: 100 mg once a day. Can be taken with or without food. • Saxagliptin: 2.5 or 5 mg once a day. Can be taken with or without food. • Linagliptin: 5 mg once a day. Can be taken with or without food. • Alogliptin:25...

Remember that this Although Symptoms of high blood sugar ( Tell your doctor right away of any serious side effects, including: signs of Get medical help right away if you have any very serious side effects, including: signs of A very serious This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking Before using this You may experience Limit alcohol while taking this medication because it can increase your risk of developing It may be harder to control your Before having surgery, tell your doctor or During pregnancy this medication should be used only when clearly needed. Pregnancy may cause or worsen It is unknown whether this drug passes into

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Sitagliptin phosphate (Januvia; Merck) was approved by the US FDA for the treatment of type 2 diabetes mellitus in October 2006. It is the first in a new class of drugs that inhibit the proteolytic activity of dipeptidyl peptidase-4, thereby potentiating the action of endogenous glucoregulatory peptides, known as incretins. Open Access articles citing this article. • • Qiu Wang • , Yu An • … Jia Liu BMC Endocrine Disorders Open Access 07 December 2022 • • Lingming Kong • , Jie Deng • … Weiming Wang Cell Death & Disease Open Access 11 October 2021 • • Shen-Liang Shih • , Yin-Shiou Lin • … Wen-Chi Hou Botanical Studies Open Access 25 February 2015 Access options • Drucker, D. J. The biology of incretin hormones. Cell Metab. 3, 153–165 (2006). • Deacon, C. F. Therapeutic strategies based on glucagon-like peptide-1. Diabetes 53, 2181–2189 (2004). • Marguet, D. et al. Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc. Natl Acad. Sci. USA 97, 6874–6879 (2000). • Ahren, B. et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes. Diabetes Care 25, 869–875 (2...

Tablets not shown at actual size. Recommended Dosing • Take JANUMET orally twice daily with meals. • Individualize the dosage of JANUMET on the basis of the patient’s current regimen, effectiveness, and tolerability. • The maximum recommended daily dose is 100 mg of sitagliptin and 2000 mg of metformin hydrochloride (HCl). • Do not split or divide JANUMET tablets. • The recommended starting dose in patients not currently treated with metformin is 50 mg sitagliptin and 500 mg metformin HCl twice daily, with gradual dose escalation recommended to reduce gastrointestinal side effects associated with metformin. • The starting dose in patients already treated with metformin should provide sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) and the dose of metformin already being taken. For patients taking metformin HCl 850 mg twice daily, the recommended starting dose of JANUMET is 50 mg sitagliptin and 1000 mg metformin HCl twice daily. Recommendations for Use in Renal Impairment • Assess renal function prior to initiation of JANUMET and periodically thereafter. • JANUMET is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m 2. • JANUMET is not recommended in patients with an eGFR between 30 and less than 45 mL/min/1.73 m 2 because these patients require a lower dosage of sitagliptin than what is available in the fixed combination JANUMET product. Acute Renal Failure There have been postmarketing reports of worse...

Dosages of Sitagliptin Tablet • 25 mg • 50 mg • 100 mg Dosage Considerations – Should be Given as Follows: • 100 mg orally once daily Dosing Modifications Renal impairment • Creatinine clearance over 50 ml/minute: dose adjustment not necessary • Creatinine clearance 30-50 ml/minute: 50 mg orally once daily • Creatinine clearance under 30 ml/minute: 25 mg orally once daily • Hepatic impairment • Mild to moderate impairment: dose adjustment not necessary • Severe impairment: not studied Pediatric: • Safety and efficacy not established What Are Side Effects Associated with Using Sitagliptin? Common side effects of sitagliptin include: • runny or • diarrhea • headache • constipation • swelling of extremities • nausea • sore throat • osteoarthritis • upper respiratory tract infection • hypersensitivity reactions (severe allergic reaction, skin swelling, rash, hives, inflamed blood vessels under the skin, and exfoliative skin conditions [including • liver enzyme elevations • • constipation • vomiting • worsening renal function, including • severe and disabling joint pain • muscle pain • pain in extremities • • low blood sugar Postmarketing side effects of sitagliptin reported include: • itching • large, fluid-filled blisters • severe allergic reaction (anaphylaxis) • skin swelling • rash • hives • inflammation of small and medium-sized vessels in the skin • Stevens-Johnson syndrome • liver enzyme elevations • acute • worsening kidney function • acute kidney failure • severe and ...

Tablets not shown at actual size. eGFR = estimated glomerular filtration rate. • There have been postmarketing reports of worsening renal function, including acute renal failure, sometimes requiring dialysis. A subset of these reports involved patients with renal impairment, some of whom were prescribed inappropriate doses of sitagliptin. A return to baseline levels of renal impairment has been observed with supportive treatment and discontinuation of potentially causative agents. Consideration can be given to cautiously reinitiating JANUVIA if another etiology is deemed likely to have precipitated the acute worsening of renal function. • Assessment of renal function is recommended prior to initiating JANUVIA and periodically thereafter. A dosage adjustment is recommended in patients with moderate or severe renal impairment and in patients with ESRD requiring hemodialysis or peritoneal dialysis. • The dosing adjustment for JANUVIA is necessary to achieve plasma concentrations of JANUVIA similar to those patients with normal renal function. 1 • Lower doses of an insulin secretagogue or insulin may be required when coadministered with JANUVIA to reduce the risk of hypoglycemia. JANUVIA is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. JANUVIA should not be used in patients with type 1 diabetes. JANUVIA has not been studied in patients with a history of pancreatitis. It is unknown whether patients with a histo...

Brand Name Generic Name Manufacturer Route Formulation Dosage Januvia sitagliptin Merck oral tablet 25 mg, 50mg, 100mg Onglyza saxagliptin Bristol-Myers Squibb oral tablet 2.5 mg, 5mg Tradjenta linagliptin Eli Lilly oral tablet 5 mg Nesina alogliptin Takeda oral tablet 6.25 mg, 12.5 mg, 25 mg Janumet sitagliptin + Merck Sharp & Dohme Corp. oral tablet 50/500 mg, 50/1000 mg Kombiglyze XR saxagliptin + metformin XR Astrazeneca oral tablet 2.5/1000 mg, 5/500 mg, 5/1000 mg Jentadueto linagliptin + metformin Boehringer Ingelheim oral tablet 2.5/500 mg, 2.5/850 mg, 2.5/1000 mg Jentadueto XR linagliptin + metformin XR Boehringer Ingelheim oral tablet 2.5/1000 mg, 5/1000 mg Kazano alogliptin + metformin hydrochloride Takeda oral tablet 12.5/500 mg, 12.5/1000 mg Oseni alogliptin + pioglitazone Takeda oral tablet 25/15 mg, 25/30 mg, 25/45 mg, 12.5/15 mg, 12.5/30 mg, 12.5/45 mg Qtern dapagliflozin + saxagliptin Astrazeneca oral tablet 10/5mg Glyxambi empagliflozin + linagliptin Boehringer Ingelheim oral tablet 10/5 mg, 25/5 mg Steglujan ertugliflozin + sitagliptin Merck oral tablet 5/100 mg, 15/100 mg There are no generic DPP-IV inhibitors availabile on the martket at this time. Patient Assistant Programs: USUAL ADULT DOSING USUAL ADULT DOSING USUAL ADULT DOSING • Sitagliptin: 100 mg once a day. Can be taken with or without food. • Saxagliptin: 2.5 or 5 mg once a day. Can be taken with or without food. • Linagliptin: 5 mg once a day. Can be taken with or without food. • Alogliptin:25...

What is metformin and sitagliptin? Metformin works by decreasing Metformin and sitagliptin is a combination medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 Metformin and sitagliptin may also be used for purposes not listed in this medication guide. Before taking this medicine You should not use metformin and sitagliptin if you are allergic to metformin or sitagliptin ( Tell your doctor if you have ever had: • kidney disease (your kidney function may need to be checked before and while you are taking this medicine); • liver disease; • heart disease; • • • • You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe If you need to have Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. This medicine is not approved for use by anyone younger than 18 years old. How should I take metformin and sitagliptin? Follow all directions on your prescription label and read all medication guides or instruction ...

Dosages of Sitagliptin Tablet • 25 mg • 50 mg • 100 mg Dosage Considerations – Should be Given as Follows: • 100 mg orally once daily Dosing Modifications Renal impairment • Creatinine clearance over 50 ml/minute: dose adjustment not necessary • Creatinine clearance 30-50 ml/minute: 50 mg orally once daily • Creatinine clearance under 30 ml/minute: 25 mg orally once daily • Hepatic impairment • Mild to moderate impairment: dose adjustment not necessary • Severe impairment: not studied Pediatric: • Safety and efficacy not established What Are Side Effects Associated with Using Sitagliptin? Common side effects of sitagliptin include: • runny or • diarrhea • headache • constipation • swelling of extremities • nausea • sore throat • osteoarthritis • upper respiratory tract infection • hypersensitivity reactions (severe allergic reaction, skin swelling, rash, hives, inflamed blood vessels under the skin, and exfoliative skin conditions [including • liver enzyme elevations • • constipation • vomiting • worsening renal function, including • severe and disabling joint pain • muscle pain • pain in extremities • • low blood sugar Postmarketing side effects of sitagliptin reported include: • itching • large, fluid-filled blisters • severe allergic reaction (anaphylaxis) • skin swelling • rash • hives • inflammation of small and medium-sized vessels in the skin • Stevens-Johnson syndrome • liver enzyme elevations • acute • worsening kidney function • acute kidney failure • severe and ...