Somatostatin is

Generic name: Other trade name: Other name: Drug Type: Sandostatin is a hormone drug that is used to treat some types of cancer. Sandostatin is classified as a somatostatin analog. (For more detail, see "How Sandostatin Works" section below). What Sandostatin Is Used For: • Sandostatin is given to control symptoms such as diarrhea or flushing in patients with tumors such as carcinoid, pancreatic islet cell tumors, gastrinoma, or vasoactive intestinal peptide-secreting tumors (VIPomas). • It is also used to treat acromegaly, when the body produces too much growth hormone, and the hands, feet, face or head grow too large. Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful. How Sandostatin Is Given: • Sandostatin has two formulations. For purposes of clarity, trade names will be used for discussion.Sandostatin is a short acting version and Sandostatin LAR is a long acting version. • Sandostatin is given by subcutaneous injection (the layer of tissue between the skin and the muscle). It may be necessary to take the shot several times a day. The injection sites should be rotated regularly. Sandostatin may also be given intravenously. • Sandostatin LAR is given by intramuscular injection (into the muscle) under a doctor's supervision. Sandostatin is generally given once every 4 weeks. The preferred site for injection is the hip, because it is painful given into the arm. Sandostatin LAR sh...

Somatostatin is a polypeptide that is released in the gastrointestinal tract by delta cells and the hypothalamus. It functions as a key regulatory peptide that has many physiologic effects as an inhibitor for many other hormones, including gastrin, cholecystokinin, glucagon, growth hormone, insulin, secretin, pancreatic polypeptide, vasoactive intestinal peptide, 5-hydroxytryptamine (5-HT), and some anterior pituitary hormones. The reference range for plasma somatostatin in adults is 10-22 pg/mL, the conversion factor is 0.426, and the SI units are 4.26-9.37 pmol/L. Draw in prechilled tube, separate plasma, and freeze immediately. [ Somatostatin is a polypeptide that is released in the gastrointestinal tract by delta cells and the hypothalamus. It functions as a key regulatory peptide that has many physiologic effects as an inhibitor for many other hormones, including gastrin, cholecystokinin, glucagon, growth hormone, insulin, secretin, pancreatic polypeptide, vasoactive intestinal peptide, 5-HT, and some anterior pituitary hormones. Lanreotide injection is used as long-term treatment for patients with acromegaly in whom surgery and/or radiotherapy have led to an inadequate response or are not an option. It is also employed to improve progression-free survival in patients with unresectable, well- or moderately differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors. [ A study by Benderradji et al found that in patients with newly diagno...

Somatostatin is indicated for: • Severe acute haemorrhage from oesophageal varices. • Severe acute haemorrhage from gastric or duodenal ulcers, or accompanying acute erosive or haemorrhagic gastritis. • Adjuvant treatment of pancreatic, biliary and intestinal fistulae. • Prophylaxis and treatment of postoperative complications following pancreatic surgery. Somatostatin is a synthetic cyclic 14 amino-acid peptide, which is identical in structure and action to natural somatostatin. By intravenous infusion in humans, somatostatin causes inhibition of growth hormone, thyroid stimulating hormone, insulin and glucagon secretion as well as inhibition of gastric acid secretion. It also affects the absorption, motility, splanchnic blood flow and trophic functions of the gastro-intestinal tract. Physiologically, somatostatin is found mainly in the gastro-intestinal tract and in the hypothalamus. Somatostatin inhibits the release of gastrin, gastric acid, and pepsin which supports its indication in the treatment of upper gastro-intestinal haemorrhage. Furthermore, somatostatin is capable of reducing remarkably splanchnic blood flow without causing significant variations in the systemic arterial pressure, which proves to be valuable for the management of oesophageal variceal haemorrhage. Somatostatin reduces both pancreatic endocrine and exocrine secretion which makes it effective in the prophylaxis and treatment of postoperative complications of pancreatic surgery. The positive effec...

Somatostatin is a hormone produced by the hypothalamus and some other tissues such as the pancreas and the gastrointestinal tract. It inhibits the release of growth hormone from the anterior pituitary, and insulin and glucagon from the pancreas. Somatostatin also decreases the release of most gastrointestinal hormones and reduces gastric acid and Somatostatin analogs are used for treatment of tumors secreting vasoactive intestinal peptide, carcinoid tumors, glucagonomas and various pituitary adenomas. It is also used to treat List of Somatostatin and somatostatin analogs Signifor LAR ( Generic name: No reviews Signifor ( Generic name: No reviews Mycapssa ( Generic name: No reviews Bynfezia Pen ( Generic name: No reviews For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum™ (updated 13 June 2023), ASHP (updated 11 June 2023) and others. • • Ad Choices • • We comply with the HONcode standard for trustworthy health information. • Copyright © 2000-2023 Drugs.com. All rights reserved.

What Is Sandostatin? Sandostatin (octreotide acetate) is an octapeptide used to treat What Are Side Effects of Sandostatin? Sandostatinmay cause serious side effects including: • hives, • difficulty breathing, • swelling of your face, lips, tongue, or throat, • severe stomach pain or tenderness, • severe constipation, • slow or uneven heartbeats, • severe pain in your upper stomach spreading to your back, • nausea, • vomiting, • fast heart rate, • increased thirst, • increased urination, • hunger, • dry mouth, • fruity breath odor, • drowsiness, • dry skin, • blurred vision, • weight loss, • headache, • hunger, • weakness, • sweating, • confusion, • irritability, • dizziness, • feeling jittery, • extreme tired feeling, • joint pain or stiffness, • muscle pain or weakness, • hoarse voice, • sensitivity to cold temperatures, and • weight gain Get medical help right away, if you have any of the symptoms listed above. Common side effects of Sandostatin include: • nausea, • vomiting, • loose/oily stools, • diarrhea, • constipation, • stomach pain or upset, • gas, • bloating, • dizziness, or • headache. Tell your doctor if you have unlikely but serious side effects of Sandostatin including: • signs of • signs of underactive • worsening heart condition symptoms (e.g., trouble breathing, slow/fast/irregular heartbeat), or • numbness or tingling of the arms or legs. Seek medical care or call 911 at once if you have the following serious side effects: • Serious eye symptoms such as ...

Somatostatinomas are a rare type of malignant tumor that grows in or around the pancreas. Doctors may also call them neuroendocrine tumors (NET) or islet cell tumors. These tumors secrete large amounts of the hormone somatostatin. Approximately Somatostatinomas are curable with surgery. During the surgery, a surgeon will remove the tumor entirely. Early diagnosis is key as the surgery becomes more complicated if the cancer has spread. Somatostatinomas occur in only In this article, we review in more detail the symptoms, causes, and treatment of somatostatinomas and the outlook for people with this tumor. Share on Pinterest PhotoAlto/Frederic Cirou/Getty Images NETs begin in the specialized cells of the neuroendocrine system. These cells produce hormones and play a role in a number of the body’s functions. NETs can develop in any part of a person’s body but commonly exist in the: • gastrointestinal tract • lungs • pancreas Somatostatinomas are a Somatostatinomas are slow-growing tumors. The symptoms are nonspecific, which means that they resemble those of other common medical problems. Most people do not have severe symptoms until the disease is very advanced. The symptoms are then similar to those that appear in other forms of • loss of appetite • • abdominal pain • frequent • unintentional weight loss Additional signs and symptoms of somatostatinomas depend on the location of the tumor, which may be in the pancreas or the small intestine. Pancreatic somatostatinomas Somat...

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing Affiliations Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary, János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary • Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing * E-mail: Affiliation Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary Fear-related memory traces are encoded by sparse populations of hippocampal principal neurons that are recruited based on their inhibitory–excitatory balance during memory formation. Later, the reactivation of the same principal neurons can recall the memory. The details of this mechanism are still unclear. Here, we investigated whether disinhibition could play a major role in this process. Using optogenetic behavioral experiments, we found that when fear was associated with the inhibition of mouse hippocampal somatostatin positive interneurons, the re-inhibition of the same interneurons could recall fear memory. Pontine nucleus incertus neurons selectively inhibit hippocampal somatostatin cells. We also found that when fear was associated with the activity of these incertus neurons o...

Generic name: Other trade name: Other name: Drug Type: Sandostatin is a hormone drug that is used to treat some types of cancer. Sandostatin is classified as a somatostatin analog. (For more detail, see "How Sandostatin Works" section below). What Sandostatin Is Used For: • Sandostatin is given to control symptoms such as diarrhea or flushing in patients with tumors such as carcinoid, pancreatic islet cell tumors, gastrinoma, or vasoactive intestinal peptide-secreting tumors (VIPomas). • It is also used to treat acromegaly, when the body produces too much growth hormone, and the hands, feet, face or head grow too large. Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful. How Sandostatin Is Given: • Sandostatin has two formulations. For purposes of clarity, trade names will be used for discussion.Sandostatin is a short acting version and Sandostatin LAR is a long acting version. • Sandostatin is given by subcutaneous injection (the layer of tissue between the skin and the muscle). It may be necessary to take the shot several times a day. The injection sites should be rotated regularly. Sandostatin may also be given intravenously. • Sandostatin LAR is given by intramuscular injection (into the muscle) under a doctor's supervision. Sandostatin is generally given once every 4 weeks. The preferred site for injection is the hip, because it is painful given into the arm. Sandostatin LAR sh...

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing Affiliations Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary, János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary • Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing * E-mail: Affiliation Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary Fear-related memory traces are encoded by sparse populations of hippocampal principal neurons that are recruited based on their inhibitory–excitatory balance during memory formation. Later, the reactivation of the same principal neurons can recall the memory. The details of this mechanism are still unclear. Here, we investigated whether disinhibition could play a major role in this process. Using optogenetic behavioral experiments, we found that when fear was associated with the inhibition of mouse hippocampal somatostatin positive interneurons, the re-inhibition of the same interneurons could recall fear memory. Pontine nucleus incertus neurons selectively inhibit hippocampal somatostatin cells. We also found that when fear was associated with the activity of these incertus neurons o...

Somatostatin is indicated for: • Severe acute haemorrhage from oesophageal varices. • Severe acute haemorrhage from gastric or duodenal ulcers, or accompanying acute erosive or haemorrhagic gastritis. • Adjuvant treatment of pancreatic, biliary and intestinal fistulae. • Prophylaxis and treatment of postoperative complications following pancreatic surgery. Somatostatin is a synthetic cyclic 14 amino-acid peptide, which is identical in structure and action to natural somatostatin. By intravenous infusion in humans, somatostatin causes inhibition of growth hormone, thyroid stimulating hormone, insulin and glucagon secretion as well as inhibition of gastric acid secretion. It also affects the absorption, motility, splanchnic blood flow and trophic functions of the gastro-intestinal tract. Physiologically, somatostatin is found mainly in the gastro-intestinal tract and in the hypothalamus. Somatostatin inhibits the release of gastrin, gastric acid, and pepsin which supports its indication in the treatment of upper gastro-intestinal haemorrhage. Furthermore, somatostatin is capable of reducing remarkably splanchnic blood flow without causing significant variations in the systemic arterial pressure, which proves to be valuable for the management of oesophageal variceal haemorrhage. Somatostatin reduces both pancreatic endocrine and exocrine secretion which makes it effective in the prophylaxis and treatment of postoperative complications of pancreatic surgery. The positive effec...