Dicyclomine

Dicyclomine Side Effects Applies to oral capsules and tablets, oral solution, parenteral injection. Side effects include: Most adverse effects are manifestations of pharmacologic effects at muscarinic-cholinergic receptors and usually are reversible when therapy is discontinued. Severity and frequency of adverse effects are dose related and individual intolerance varies greatly; although adverse effects occasionally may be obviated by a reduction in dosage, this also will likely eliminate potential therapeutic effects. If dosage of ≥80 mg daily cannnot be achieved because of intolerance, discontinue dicyclomine. Dry mouth, For Healthcare Professionals Applies to dicyclomine: compounding powder, intramuscular solution, oral capsule, oral syrup, oral tablet. General -The most serious adverse reactions include cardiovascular and central nervous system symptoms. -The most common adverse reactions are dizziness, dry mouth, vision blurred, nausea, somnolence, asthenia and nervousness, [ Gastrointestinal Very common (10% or more): Dry mouth (33%), nausea (14%) Rare (less than 0.1%): Frequency not reported: Thirst, Postmarketing reports: Abdominal distension, abdominal [ Nervous system Very common (10% or more): Dizziness (40%) Common (1% to 10%): Somnolence, nervousness Rare (less than 0.1%): Postmarketing reports: Dizziness, headache, somnolence, [ Ocular Very common (10% or more): Blurred vision (27%) Frequency not reported: Follicular Postmarketing reports: Cycloplegia, mydria...

What is this medication? DICYCLOMINE (dye SYE kloe meen) treats irritable bowel syndrome (IBS). It works by relaxing the muscles of your stomach and bowel, which reduces cramping. It belongs to a group of medications called antispasmodics. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. COMMON BRAND NAME(S): Bentyl What should I tell my care team before I take this medication? They need to know if you have any of these conditions: • Difficulty passing urine • Esophagus problems or heartburn • Glaucoma • Heart disease, or previous heart attack • Myasthenia gravis • Prostate trouble • Stomach infection, or obstruction • Ulcerative colitis • An unusual or allergic reaction to dicyclomine, other medications, foods, dyes, or preservatives • Pregnant or trying to get pregnant • Breast-feeding How should I use this medication? Take this medication by mouth with a glass of water. Follow the directions on the prescription label. It is best to take this medication on an empty stomach, 30 minutes to 1 hour before meals. Take your medication at regular intervals. Do not take your medication more often than directed. Talk to your care team about the use of this medication in children. Special care may be needed. While this medication may be prescribed for children as young as 6 months of age for selected conditions, precautions do apply. Patients over 65 years old may have a stronger reaction and need a smaller dose. Over...

Bentyl (dicyclomine) and Librax (chlordiazepoxide and clidinium bromide) are prescribed to treat irritable bowel syndrome (IBS). Librax is also used to treat stomach ulcers and intestinal disorders. Bentyl is an anticholinergic and Librax is a combination of a benzodiazepine and an anticholinergic/spasmolytic. Answer Can I buy Bentyl over the counter? No: it is a prescription medication with no OTC counterpart but it is not scheduled so your physician can prescribe refills. Ask U.S. doctors your own question and get educational, text answers — it’s anonymous and free! Doctors typically provide answers within 24 hours. How long does it take for dicyclomine to wear off? It is most commonly used for irritable bowel syndrome. It is also known generically as dicyclomine. Though rare, some people abuse this medication to experience euphoria. Its peak effects are felt within 90 minutes of use, though dicyclomine has a half-life of nine to 10 hours. This drug is not commonly tested in drug screenings. What Is Bentyl? Does dicyclomine cause addiction? Though it is relatively safe to use, the medication can cause dependency and become habit-forming. How Dicyclomine Works Dicyclomine works by decreasing a chemical messenger (neurotransmitter) called acetylcholine . How long does it take for the dicyclomine to work? Peak levels of dicyclomine are reached within 60 to 90 minutes and a reduction in colicky symptoms and muscle spasms should be seen within that time. Effects are relativel...

Dosage Forms Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product Capsule, Oral, as hydrochloride: Bentyl: 10 mg [DSC] [contains brilliant blue fcf (fd&c blue #1), corn starch, fd&c red #40] Generic: 10 mg Solution, Intramuscular, as hydrochloride: Bentyl: 10 mg/mL (2 mL) [pyrogen free] Generic: 10 mg/mL (2 mL) Solution, Intramuscular, as hydrochloride [preservative free]: Generic: 10 mg/mL (2 mL) Solution, Oral, as hydrochloride: Generic: 10 mg/5 mL (473 mL) Tablet, Oral, as hydrochloride: Bentyl: 20 mg [DSC] [contains brilliant blue fcf (fd&c blue #1), corn starch] Generic: 20 mg Pharmacology Mechanism of Action Blocks the action of acetylcholine at parasympathetic sites in smooth muscle, secretory glands and the CNS Pharmacokinetics/Pharmacodynamics Absorption Oral: Rapid and well absorbed Distribution V d: 3.65 L/kg Metabolism Extensive Excretion Urine (80%, small amounts as unchanged drug); feces (8%) Onset of Action 1 to 2 hours Time to Peak Oral: 60 to 90 minutes Duration of Action Up to 4 hours Half-Life Elimination Initial phase: ~1.8 hours; Terminal phase: Undetermined, but somewhat longer than the initial phase Use: Labeled Indications Irritable bowel syndrome: Treatment of irritable bowel syndrome-associated abdominal pain. Contraindications Obstructive diseases of the GI tract; severe ulcerative colitis; reflux esophagitis; unstable cardiovascular status in acute he...

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Usual Adult Dose for: • Additional dosage information: • • • • • Usual Adult Dose for Irritable Bowel Syndrome Oral: Initial dose: 20 mg orally four times a day Maintenance dose: Up to 40 mg orally four times a day, after one week with initial dose Comments: • Discontinue this drug if efficacy is not achieved within 2 weeks or side effects require doses below 80 mg per day. • Documented safety data are not available for doses above 80 mg daily for periods longer than 2 weeks. Intramuscular: 10 to 20 mg four times a day Duration of therapy: 1 or 2 weeks, when patient cannot take oral form Comments: Administer injection via IM only Uses: Treatment of patients with functional bowel/irritable bowel syndrome Renal Dose Adjustments Data not available Liver Dose Adjustments Data not available Precautions Safety and efficacy have not been established in patients younger than 18 years. Dicyclomine is contraindicated in infants under 6 months of age. Consult WARNINGS section for additional precautions. Dialysis Data not available Other Comments Administration advice: • Dicyclomine injection is for IM administration only. • Inspect parenteral products visually for particulate matter and discoloration prior administration. • Aspirate the syringe before injecting to avoid intravascular injection (thrombosis may occur if the drug is inadvertently injected intravascularly). Patient advice: This drug may cause drowsiness or blurred vision; avoid activities that require mental alertness, s...

Bentyl is a brand name for the medication dicyclomine. The Food and Drug Administration (FDA) first approved its use in the United States in It acts as an Additionally, as an antispasmodic, it Bentyl is available in the following forms: • capsule • tablet • syrup • injection A person should speak with a doctor before using Bentyl. People with IBS often experience cramps and irregular bowel movements due to painful contractions of the gut muscles. Bentyl can help relieve involuntary muscle spasms and other accompanying symptoms of IBS. A doctor may recommend Bentyl as a short- or long-term treatment option for IBS. Many people experience relief within hours of taking the medication. A What symptoms Bentyl improves Although doctors frequently prescribe Bentyl to treat IBS, there is limited research on its effectiveness. In a • • gastrointestinal tenderness • bowel function • overall IBS symptoms However, most participants who took dicyclomine instead of a placebo had some side effects, including: • • • A person can take Bentyl by mouth as directed by a doctor, usually To reduce the risk of side effects, a doctor will start a person on a low dose and gradually increase the dose while monitoring their symptoms. Dosage A doctor The doctor will adjust an individual’s dosage to meet their needs. However, the doctor may not increase a person’s dose if they have side effects. For people who cannot take medication orally, health experts recommend intramuscular injections of 10–20 mg...