Difference between thalassemia and sickle cell anaemia

Sickle cell beta-thalassemia refers to an inherited condition that impacts hemoglobin. People with the condition have different changes in each copy of their hemoglobin gene. One causes red blood cells (RBCs) to form a sickle shape and another reduces the amount of hemoglobin. Sickle cell beta-thalassemia is a type of Both In this article, we will discuss the causes and risk factors for sickle cell beta-thalassemia, as well as symptoms and treatment options for the condition. Sickle cell beta-thalassemia results from a change in the beta-hemoglobin (HBB) gene. The beta-hemoglobin gene is responsible for forming the hemoglobin subunit beta component of the hemoglobin protein. A person develops sickle cell beta-thalassemia when they inherit one sickle cell trait from one parent and one beta-thalassemia trait from the other. The beta-thalassemia gene Risk factors for a person developing sickle cell beta-thalassemia include having parents that may be carriers of the sickle cell, HbS beta+, or HbS beta0 gene. The condition follows an autosomal recessive inheritance pattern. This means that if a person has a beta-thalassemia trait and their partner has a sickle cell trait, there is a The symptoms a person may experience will depend on whether they have HbS beta+ or HbS beta0. The amount of normal hemoglobin a person can produce A person with HbS beta+ will likely have milder symptoms, as while they produce less functioning hemoglobin than is typical, they can still produce norma...

Blood disorders are conditions that keep parts of your blood from doing their jobs. You may have a blood clotting disorder or a bleeding disorder. With treatment, most blood disorders become chronic illnesses that don’t affect people’s lifespans. Treatment includes managing symptoms and treating any underlying conditions. Overview What are blood disorders? Blood disorders are conditions that keep parts of your blood from doing their jobs: • Your • Your • Your Blood disorders may be You may inherit a noncancerous blood disorder or develop one because you have an underlying condition that affects your blood. Some blood disorders may not cause symptoms or require treatment. Others are chronic (lifelong) illnesses that require treatment but typically won’t affect how long you’ll live. Other blood disorders are serious illnesses that can be life-threatening. Healthcare providers treat blood disorders by managing symptoms and treating any underlying conditions. How do blood disorders affect my body? In general, noncancerous blood disorders are conditions that affect your blood cells and platelets and cause issues that may: • Increase your risk of blood clots. • Make you bleed more than normal because your blood doesn’t form What are common blood clotting disorders? A • Prothrombin gene mutation: This inherited disorder increases your risk of developing abnormal blood clots in your veins ( • Antiphospholipid syndrome: This rare • Protein S deficiency: Protein S is a natural antic...

Anemia and leukemia are both conditions that affect a person’s blood. Although there is no evidence that anemia can cause leukemia, people with leukemia are more likely to develop anemia. This could be because leukemia, a form of blood cancer, causes anemia, which involves a reduction in red blood cells. Moreover, some leukemia treatments also cause anemia. This article focuses on two conditions: leukemia and anemia, which both affect the blood. After exploring the link between leukemia and anemia, this article will compare their types, causes, symptoms, diagnosis, and treatment. The Acute vs. chronic leukemia A person has acute leukemia when it affects younger, less mature cells. Chronic leukemia, by contrast, affects older cells. The condition heavily affects these older cells, despite being more mature. Additionally, acute leukemias also progress quickly, while chronic leukemias tend to develop slowly. Myeloid vs. lymphocytic leukemia This refers to the effect on the different types of blood cells. A person has lymphocytic leukemia when their cancer affects white blood cells known as lymphocytes. Myeloid leukemia instead affects myeloid cells, such as white blood cells other than lymphocytes, red blood cells, and platelets. As a Hyperproliferative anemia A person has this form of anemia when their red blood cells are lost or destroyed too quickly. Hypoproliferative anemia An individual has this form of anemia when their bone marrow does not produce enough red blood cell...

This article was published in December 2008 as part of the special ASH anniversary brochure, Sickle cell disease and thalassemia are genetic disorders caused by errors in the genes for hemoglobin, a substance composed of a protein ("globin") plus an iron molecule ("heme") that is responsible for carrying oxygen within the red blood cell. These disorders can cause fatigue, jaundice, and episodes of pain ranging from mild to very severe. They are inherited, and usually both parents must pass on an abnormal gene in order for a child to have the disease. When this happens, the resulting diseases are serious and, at times, fatal. Sickle Cell Disease Sickle cell disease was first discovered in the early 1900s, described as "peculiar, elongated sickle-shaped erythrocytes [red blood cells]." With further study, a noted pathologist later suggested that the pain experienced by sickle cell patients resulted from the blockage of tiny blood vessels. In a landmark 1949 study, Dr. Linus Pauling concluded that sickle cell disease is caused by abnormal hemoglobin, referred to as "hemoglobin S." The disease was among the first to be understood fully at the biochemical level, as researchers learned that the abnormal hemoglobin was actually changing shape (called "sickling") due to a single amino acid error in hemoglobin S. Even though the underlying molecular cause of the disease was understood more than half a century ago, progress in translating this knowledge into improved patient care ha...