H2n2 virus symptoms

• Article • 03 February 2022 Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial • ORCID: orcid.org/0000-0002-2147-186X • • • • • • • • • • • • • • • • • • ORCID: orcid.org/0000-0003-4113-5473 • • • • ORCID: orcid.org/0000-0001-5741-3699 • ORCID: orcid.org/0000-0002-3087-8397 • ORCID: orcid.org/0000-0001-5767-1532 • • ORCID: orcid.org/0000-0002-2583-1949 • • ORCID: orcid.org/0000-0003-3161-1624 • • • • • ORCID: orcid.org/0000-0001-5568-5420 • ORCID: orcid.org/0000-0002-0337-5823 • • ORCID: orcid.org/0000-0003-0616-9117 • • • • • • • Show authors Nature Medicine volume 28, pages 383–391 ( 2022) Currently, licensed seasonal influenza vaccines display variable vaccine effectiveness, and there remains a need for novel vaccine platforms capable of inducing broader responses against viral protein domains conserved among influenza subtypes. We conducted a first-in-human, randomized, open-label, phase 1 clinical trial ( n = 5) or a 60-μg dose either twice in a homologous ( n = 25) prime-boost regimen or once in a heterologous ( n = 20) prime-boost regimen after a matched H2 DNA vaccine prime. The primary objective of this trial was to evaluate the safety and tolerability of H2HA-Ferritin either alone or in prime-boost regimens. The secondary objective was to evaluate antibody responses after vaccination. Both vaccines were safe and well tolerated, with the most common solicited symptom being mild headache after both H2HA-Fer...

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