Howell jolly bodies

Author:John Lazarchick Category: Red Cell: Disorders of Iron Metabolism and Heme Synthesis > Hemochromatosis Published Date:03/17/2014 This image best illustrates the difference between Pappenheimer bodies and Howell-Jolly bodies. The large arrow depicts a RBC with a Howell-Jolly body. Note: this is a single round dense structure with a regular borderas opposed to the Pappenheimer bodies (small arrow)which are frequently multiple inclusions with irregular borders. Howell-Jolly bodies are fragments of DNA and typically seen in the peripheral smears of individuals with sickle cell disease following auto-splenectomy. A nucleated RBC is also present in this view. Pappenheimer bodies are abnormal granules of iron found inside red blood cells on a routine blood stain.

Verywell / Danie Drankwalter Types Megaloblastic anemia is a type of macrocytic anemia. Macrocytic anemia includes all types of anemia with larger than normal red blood cells. They can be megaloblastic (with enlarged and unusual red blood cell precursors in the bone marrow) or non-megaloblastic, and the causes of each type differ. • B12 level below 200 picograms per milliliter (pg/mL) is considered low. • Folate level below 2 nanograms per milliliter (ng/mL) is considered low. • Low levels of gastrin (a hormone that triggers the release of digestive juices) and the presence of intrinsic factor antibodies or parietal cell antibodies can occur with pernicious anemia. • A • An • Imaging tests may be needed if there is concern that you could have a change in your gastrointestinal system that is visible with an abdominal computerized tomography (CT) (detailed imaging using X-rays) or ultrasound (imaging using sound waves). A Word From Verywell Anemia is not uncommon, and you might have anemia at some time in your life. If you are diagnosed with megaloblastic anemia or any other type of anemia, it’s important that you follow through with a comprehensive evaluation of the cause. Rest assured that most of the time, megaloblastic anemia can be treated, and your symptoms should improve with treatment. • National Organization of Rare Disorders. • Albai O, Timar B, Paun DL, Sima A, Roman D, Timar R. Diabetes Metab Syndr Obes. 2020;13:3873-3878. doi:10.2147/DMSO.S270393 • Htut TW, Thei...

A 2-year-old boy with VACTERL association with multiple congenital anomalies was hospitalized with fever without a source. He was 4 months status post–deceased donor renal transplant for solitary dysplastic kidney. Immunosuppression included tacrolimus and azathioprine. History was otherwise notable for chronic Epstein-Barr viremia without evidence of posttransplant lymphoproliferative disorder. Complete blood count revealed a white blood cell count of 1.8 × 10 9/L, a hemoglobin level of 7.0 g/dL, and a platelet count of 402 × 10 9/L, with an absolute neutrophil count of 0.7 × 10 9/L. Review of the peripheral blood film showed bilobed and occasionally hypogranular neutrophils containing round basophilic inclusions consistent with micronuclei (panels A-D). These were present in 11% of neutrophils and were absent from other leukocytes. Although the morphology of these inclusions was not entirely typical of Anaplasma phagocytophilum, he received a course of doxycycline for this infection due to his residence in an area where tick-borne infections are endemic. The inclusions persisted at stable frequency after treatment. Howell-Jolly–like bodies in granulocytes arise secondary to stressed granulopoiesis induced by immunosuppressive drugs, viral infection, or chemotherapy, and must be differentiated from other neutrophil inclusions such as those observed in intracellular bacterial infections, genetic conditions such as Chédiak-Higashi syndrome, or Döhle bodies [ Arch Pathol Lab...