Influenza virus h3n2

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. MRNA-1083 overview mRNA-1083 is under development for the prevention of influenza virus infection caused by influenza A/H1N1, A/H3N2, and influenza B/Yamagata and B/Victoria strains and coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in 18 to 79 years of age group. It is a combination vaccine of mRNA-1283, which encodes Receptor Binding Doman (RBD) and N-Terminal Domain (NTD) of the spike protein and mRNA-1010, which encodes hemagglutinin (HA) glycoproteins of influenza A/H1N1, A/H3N2, and influenza B/Yamagata and B/Victoria-lineages. It is administered through intramuscular route in the form of sterile liquid for injection. Moderna overview For a complete picture of MRNA-1083’s drug-specific PTSR and LoA scores, GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s

• Article • • 14 September 2021 Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses • • • • • • • ORCID: orcid.org/0000-0003-1768-582X • ORCID: orcid.org/0000-0001-9866-8903 • ORCID: orcid.org/0000-0001-8095-2869 • • … • ORCID: orcid.org/0000-0003-3111-5954 Show authors Nature Communications volume 12, Article number: 5449 ( 2021) During circulation in humans and natural selection to escape antibody recognition for decades, A/H3N2 influenza viruses emerged with altered receptor specificities. These viruses lost the ability to agglutinate erythrocytes critical for antigenic characterization and give low yields and acquire adaptive mutations when cultured in eggs and cells, contributing to recent vaccine challenges. Examination of receptor specificities of A/H3N2 viruses reveals that recent viruses compensated for decreased binding of the prototypic human receptor by recognizing α2,6-sialosides on extended LacNAc moieties. Erythrocyte glycomics shows an absence of extended glycans providing a rationale for lack of agglutination by recent A/H3N2 viruses. A glycan remodeling approach installing functional receptors on erythrocytes, allows antigenic characterization of recent A/H3N2 viruses confirming the cocirculation of antigenically different viruses in humans. Computational analysis of HAs in complex with sialosides having extended LacNAc moieties reveals that mutations distal to the RBD reoriented the Y159 side chain resul...

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. We talked with infectious disease doctor “What all flu strains have in common are the symptoms they cause,” Dr. Mossad says. “Fever. Headache. Cough. Those are the three cardinal manifestations of all flu viruses. Flu can cause stomach issues for some people, too, but ‘stomach flu’ is really a misnomer.” What are the strains of flu? There are three types of flu viruses that affect people. They’re known as influenza viruses A, B and C. Influenza A and influenza B viruses are the heavy hitters. They’re the ones that cause the most severe illness and lead to widespread outbreaks. Influenza C viruses cause mild illnesses in people. They’re more similar to a common cold, Dr. Mossad says, and they aren’t detected by flu tests. (Fun fact: There is an influenza D virus, but it’s mostly found in cattle and hasn’t been known to affect people.) When people talk about the flu, it’s really influenza A and B viruses. They’re the viruses that are responsible for our annual flu season. Influenza A Influenza A viruses are the most common flu viruses. They’re the cause of regular seasonal flu outbreaks, as well as global flu pandemics. Influenza A viruses can affect both people and animals. The 1918 pandemic and the 2009 H1N1 pandemic (what some people call the “swine flu”), for example, were Influenza A virus outbreaks. Dr...