Natural history of disease

• • Cytokine storm is a complication factor in COVID-19 infections. • • Repurposed drugs are currently being tested under off-label emergencial approval in COVID-19 patients. • • Interferon, lopinavir and ritonavir show promising results in clinical trials against SARS-CoV-2. • • Anakinra seems promising for the treatment of severe forms of COVID-19. • • COVID-19 vaccines are already under clinical trials and are expected to be available until the end of 2020. Despite intense research there is currently no effective vaccine available against the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in the later 2019 and responsible for the COVID-19 pandemic. This infectious and communicable disease has become one of the major public health challenges in the world. The clinical management of COVID-19 has been limited to infection prevention and control measures associated with supportive care such as supplemental oxygen and mechanical ventilation. Meanwhile efforts to find an effective treatment to inhibit virus replication, mitigate the symptoms, increase survival and decrease mortality rate are ongoing. Several classes of drugs, many of them already in use for other diseases, are being evaluated based on the body of clinical knowledge obtained from infected patients regarding to the natural history and evolution of the infection. Herein we will provide an updated overview of the natural history and current knowledge on drugs and therapeutic agents being...

• Leonard Sinclair , emeritus consultant paediatrician, Chelsea and Westminster Hospital, London • Drlsgotadsl.co.uk John Ryle came from the school of master clinicians who walked the wards and tended the needs of patients (at Guy’s Hospital, London). He was a physician who listened but was also noted for his clinical research on gastric function. “Ryle’s tube” was for many years the eponymous name for that tube used for emptying the stomach and for gastric lavage. His mentor was Arthur Hurst, the doyen of gastroenterologists in the 1920s, and he dedicated this book to him. It was written at a time when Ryle had accumulated much clinical experience and was under …

• Article • • 03 February 2021 The natural history of symptomatic COVID-19 during the first wave in Catalonia • ORCID: orcid.org/0000-0002-9286-1128 • • • ORCID: orcid.org/0000-0002-5990-6953 • • ORCID: orcid.org/0000-0002-1964-3546 • ORCID: orcid.org/0000-0003-1202-9153 • ORCID: orcid.org/0000-0002-3950-6346 • … • Show authors Nature Communications volume 12, Article number: 777 ( 2021) The natural history of coronavirus disease 2019 (COVID-19) has yet to be fully described. Here, we use patient-level data from the Information System for Research in Primary Care (SIDIAP) to summarise COVID-19 outcomes in Catalonia, Spain. We included 5,586,521 individuals from the general population. Of these, 102,002 had an outpatient diagnosis of COVID-19, 16,901 were hospitalised with COVID-19, and 5273 died after either being diagnosed or hospitalised with COVID-19 between 1st March and 6th May 2020. Older age, being male, and having comorbidities were all generally associated with worse outcomes. These findings demonstrate the continued need to protect those at high risk of poor outcomes, particularly older people, from COVID-19 and provide appropriate care for those who develop symptomatic disease. While risks of hospitalisation and death were lower for younger populations, there is a need to limit their role in community transmission. The natural history of coronavirus disease 2019 (COVID-19) has yet to be well-established. While a wide range of studies have described outcomes amon...

• • Machine translation, like • Consider |topic= will aid in categorization. • Do not translate text that appears unreliable or low-quality. If possible, verify the text with references provided in the foreign-language article. • You must provide Content in this edit is translated from the existing Spanish Wikipedia article at [[:es:Historia natural de la enfermedad]]; see its history for attribution. • You should also add the template to the • For more guidance, see Autopsy (1890) by The natural history of disease is the course a As an example, the cartilage of the knee, trapeziometacarpal and other joints deteriorates with age in most humans (osteoarthritis). There are no The subclinical (pre-symptomatic) and clinical (symptomatic) evolution of disease is the natural progression of a disease without any medical intervention. It constitutes the course of biological events that occurs during the development of a disease from its root causes ( In regards to the natural history of disease, the goal of the medical field is to discover all of the different phases and components of each pathological process in order to intervene as early as possible and change the course of the disease before it leads to the deterioration of a patient's There are two complementary perspectives for characterizing the natural history of disease. The first is that of the Phases of disease [ ] Pre-pathogenic period [ ] In the pre-pathogenic period, the disease originates, but the patient doesn't y...