Ofloxacin structure

WARNING: SERIOUS ADVERSE REACTIONS INCLUDING TENDINITIS, TENDON RUPTURE, PERIPHERAL NEUROPATHY, CENTRAL NERVOUS SYSTEM EFFECTS AND EXACERBATION OF MYASTHENIA GRAVIS Fluoroquinolones, including Ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions that have occurred together, including: • Tendinitis and tendon rupture • Peripheral neuropathy • Central nervous system effects (see Discontinue Ofloxacin immediately and avoid the use of fluoroquinolones, including Ofloxacin, in patients who experience any of these serious adverse reactions (see • Fluoroquinolones, including Ofloxacin, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid Ofloxacin in patients with known history of myasthenia gravis (see • Because fluoroquinolones, including Ofloxacin, have been associated with serious adverse reactions (see • Acute exacerbation of chronic bronchitis • Uncomplicated cystitis (see To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ofloxacin tablets and other antibacterial drugs, Ofloxacin tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Ofloxacin Description Ofloxacin tablets are a synthetic broad-spectrum antimicrobial agent for oral administration. Chemically, Ofloxacin,USP, a fluorinated carboxyquinolone, is the racemate, (±)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7 H-pyrido[1,2,...

Warnings Ofloxacin can cause serious side effects, including tendon problems, nerve damage, serious mood or behavior changes, or Stop using ofloxacin and call your doctor at once if you have symptoms such as: In rare cases, ofloxacin may cause damage to your aorta, which could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back. Related/similar drugs Before taking this medicine You should not use this medicine if you are allergic to ofloxacin or other Ofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. This can happen during treatment or up to several months after you stop taking ofloxacin. Tendon problems may be more likely in certain people (children and older adults, or people who use steroid medicine or have had an Tell your doctor if you have ever had: • tendon problems, bone problems, arthritis, or other joint problems; • blood circulation problems, aneurysm, narrowing or hardening of the arteries; • heart problems, • a genetic disease such as • diabetes; • a muscle or nerve disorder, such as • liver or kidney disease; • a seizure; • • low levels of potassium in your blood ( Ofloxacin is not approved for use by anyone younger than 18 years old. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant. You should not breast-feed while using th...

The newer fluoroquinolones have broad-spectrum bactericidal activity, excellent oral bioavailability, good tissue penetration and favorable safety and tolerability profiles. A new four-generation classification of the quinolone drugs takes into account the expanded antimicrobial spectrum of the more recently introduced fluoroquinolones and their clinical indications. First-generation drugs (e.g., nalidixic acid) achieve minimal serum levels. Second-generation quinolones (e.g., ciprofloxacin) have increased gram-negative and systemic activity. Third-generation drugs (e.g., levofloxacin) have expanded activity against gram-positive bacteria and atypical pathogens. Fourth-generation quinolone drugs (currently only trovafloxacin) add significant activity against anaerobes. The quinolones can be differentiated within classes based on their pharmacokinetic properties. The new classification can help family physicians prescribe these drugs appropriately. With the increasing number of available quinolone antibiotics, prescribing these drugs has become a challenge. Compared with older quinolones such as norfloxacin (Noroxin) and ciprofloxacin (Cipro), the newer agents have an expanded antimicrobial spectrum and new indications. The most recently released agents have significant antimicrobial activity against gram-positive streptococci, atypical pathogens and anaerobes. The new classification of quinolone antibiotics by generation can help family physicians prescribe these agents ap...

More details: • Systematic name 9-Fluoro-3-methyl-10 -(4-methyl-1-piperaz inyl)-7-oxo-2,3-dihy dro-7H-[1,4]oxazino[ 2,3,4-ij]quinoline-6 -carboxylic acid • SMILES CC1COc2c3n1cc(c(=O)c 3cc(c2N4CCN(CC4)C)F) C(=O)O • Std. InChi InChI=1S/C18H20FN3O4 /c1-10-9-26-17-14-11 (16(23)12(18(24)25)8 -22(10)14)7-13(19)15 (17)21-5-3-20(2)4-6- 21/h7-8,10H,3-6,9H2, 1-2H3,(H,24,25) • Std. InChIKey • Cite this record CSID:4422, http://www.chemspider.com/Chemical-Structure.4422.html (accessed 23:22, Jun 15, 2023) • Experimental Physico-chemical Properties • Experimental Melting Point: 253.5 °C Jean-Claude Bradley Open Melting Point Dataset 218-220 °C Oakwood 254 °C (Decomposes) Parchem – fine & specialty chemicals 218-220 °C Oakwood • Experimental Solubility: 10 mM in DMSO MedChem Express DMSO 0.4 mg/mL; Water <1 mg/mL MedChem Express • Miscellaneous • Safety: J01MA01 Wikidata S01AE01 Wikidata S02AA16 Wikidata • Target Organs: Topoisomerase inhibitor TargetMol • Chemical Class: An oxazinoquinolone carrying carboxy, fluoro, methyl and 4-methylpiperazino substituents. A synthetic fluoroquinolone antibacterial agent, it inhibits the supercoiling activity of bacterial DNA gyrase , halting DNA replication. ChEBI • Bio Activity: Antibacterial MedChem Express Anti-infection MedChem Express Anti-infection; MedChem Express DNA Damage/DNA Repair TargetMol Ofloxacin is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. MedChem Express Ofloxacin is a fluoroquinolon...