Omeprazole

Contents • 1 Medical uses • 1.1 Peptic ulcers • 2 Adverse effects • 2.1 Long-term use • 2.2 Pregnancy and breastfeeding • 3 Interactions • 4 Pharmacology • 4.1 Mechanism of action • 4.2 Pharmacokinetics • 5 Chemistry • 5.1 Measurement in body fluids • 6 History • 7 Society and culture • 7.1 Brand names • 8 References • 9 Further reading • 10 External links Adverse effects Adverse effects occurring in at least 1% of people include: [ failed verification] • Central nervous system: headache (7%), dizziness (2%) • Respiratory: • Gastrointestinal: abdominal pain (5%), diarrhea (4%), nausea (4%), vomiting (3%), flatulence (3%), acid regurgitation (2%), constipation (2%) • Neuromuscular and skeletal: back pain (1%), weakness (1%) • Dermatologic: rash (2%) Other concerns related to adverse effects are: • Recurrence of • • Concern has been expressed regarding 12 Since their introduction, proton-pump inhibitors (PPIs, especially omeprazole) have also been associated with several cases of Long-term use Long-term use of PPIs is strongly associated with the development of benign There is a possible association between long term use and dementia which requires further study to confirm. A review article in Pregnancy and breastfeeding The safety of using omeprazole has not been established in pregnant or breastfeeding women. No • Omeprazole has a high plasma protein binding rate (95%), • Omeprazole needs to be administered in an enteric-coated formulation due to its rapid degradation in t...