Anisole 5.0 Write a review anhydrous, 99.7% Synonym (s): Methoxybenzene, Methyl phenyl ether Linear Formula: CH3OC6H5 CAS Number: 100-66-3 Molecular Weight: 108.14 Beilstein: 506892 EC Number: 202-876-1 MDL number: MFCD00008354 eCl@ss: 39023603 PubChem Substance ID: 57648387 NACRES: NA.21 Pricing and availability is not currently available.

3 Answers Sorted by: 28 Like aniline, phenol too reacts to a very less extent during Friedel-Crafts reaction. The reason being that the oxygen atom of phenol has lone pair of electrons which coordinate with Lewis acid. In fact most substituents with lone pair would give poor yield.