Sitagliptin and metformin

Usual Adult Dose for: • Additional dosage information: • • • • • • Usual Adult Dose for Diabetes Type 2 Dose should be individualized based on patient's current regimen, effectiveness, and tolerability. IMMEDIATE-RELEASE: • Initial dose for patients not receiving metformin: sitagliptin 50 mg/metformin 500 mg orally twice a day • Initial dose for patients receiving metformin: sitagliptin 50 mg in combination with half the daily dose of metformin orally twice a day (i.e, equal to same total daily dose of metformin currently being administered) EXTENDED-RELEASE: • Initial dose for patients not receiving metformin: sitagliptin 100 mg/metformin 1000 mg orally once a day • Initial dose for patients receiving metformin: sitagliptin 100 mg in combination with current daily metformin dose orally once a day TITRATE metformin dose slowly to reduce gastrointestinal side effects; titrate combination dose to achieve optimal glycemic control MAXIMUM: Sitagliptin 100 mg/day; Metformin 2000 mg/day Comments: • The same daily dose of metformin and sitagliptin should be maintained if need to change between immediate-release and extended-release products. • When initiating therapy, a dose adjustment of insulin secretagogue (e.g., sulfonylurea) or insulin may be necessary to reduce the risk of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. Renal Dose Adjustments Mild renal impairment (eGFR greater than 45 mL/min/1.73 ...

• Sitagliptin/metformin, sold under the brand name Janumet among others, is a Common side effects include diarrhea, headache, and upper respiratory tract infections. The combination was approved for medical use in the United States in 2007. million prescriptions. Medical uses [ ] In the United States, sitagliptin/metformin is In the European Union, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in people with type 2 diabetes; in combination with a In December 2020, the U.S. Society and culture [ ] Brand names [ ] As of 2018, the combination was marketed under several brand names, including Efficib, Zaxoran, Janmet, Januet, Janumet, Jznumet, Ristaben Met, Ristfor, Siglimet, Sitamet, Sitar-M, Sliptin-M, Treviamet, and Velmetia. References [ ] • ^ a b c d e Drugs.com. . Retrieved 19 April 2019. • (emc). 25 November 2020. . Retrieved 5 December 2020. • ^ a b DailyMed. 12 August 2019. . Retrieved 5 December 2020. • ^ a b DailyMed. . Retrieved 5 December 2020. • ^ a b . Retrieved 5 December 2020. • ^ a b c British national formulary: BNF 76 (76ed.). Pharmaceutical Press. 2018. p.682. 9780857113382. • Hayes J, Anderson R, Stephens JW (2016). Drug Design, Development and Therapy. 10: 2263–70. • Drugs.com. . Retrieved 19 April 2019. • ClinCalc . Retrieved 7 October 2022. • ClinCalc . Retrieved 7 October 2022. • . Retrieved 3 August 2022. • . Retrieved 28 January 2023. • ^ a b U.S. Food and Drug Administration. 4 December 2020. . Re...

Read the Take this medication by The dosage is based on your medical condition, response to treatment, and other Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Carefully follow the medication treatment plan, meal plan, and Tell your doctor if your condition does not improve or if it worsens (your See also Warning section. Remember that this Tell your doctor right away if you have any serious side effects, including: Get medical help right away if you have any very serious side effects, including: signs of disease of the This medication does not usually cause Symptoms of high blood sugar ( A very serious This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. See also Warning section. Before taking this Before using this medication, tell your doctor or pharmacist your medical history, especially of: Before having surgery or any X-ray/scanning procedure using iodinated contrast, tell your doctor or You may experience Limit alcohol while taking this medication because it can increase your risk of developing It may be harder to control your Older adul...

Check with your doctor immediately if any of the following side effects occur: Less common • Anxiety • blurred vision • chills • cold sweats • confusion • cool, pale skin • depression • dizziness • fast heartbeat • headache • increased hunger • loss of consciousness • mental cloudiness • nausea • nightmares • not thinking clearly • seizures • shakiness • slurred speech • unusual tiredness or weakness Rare • Decreased appetite • diarrhea • fast, shallow breathing • general feeling of discomfort • muscle pain or cramping • sleepiness • stomach discomfort Incidence not known • Blistering, peeling, or loosening of the skin • darkened urine • hives or welts, itching, or skin rash • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs • loss of appetite • pains in the stomach, side, or abdomen, possibly radiating to the back • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue • red skin lesions, often with a purple center • severe joint pain • sores, ulcers, or white spots in the mouth or on the lips • vomiting • yellow eyes or skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bot...

Description and Brand Names Drug information provided by: US Brand Name • Januvia Descriptions Sitagliptin is used alone or together with other medicines (eg, insulin, glimepiride, metformin, or pioglitazone) and with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood. This medicine does not help patients who have insulin-dependent or type 1 diabetes. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: • Tablet Before Using In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of sitagliptin in the pediatric population. Safety and efficacy have not been establishe...

Oral route(Tablet;Tablet, Extended Release) Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. Symptoms included malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Laboratory abnormalities included elevated blood lactate levels, anion gap acidosis, an increased lactate/pyruvate ratio, and metformin plasma levels generally greater than 5 mcg/mL. Risk factors include renal impairment, concomitant use of certain drugs (eg, carbonic anhydrase inhibitors), age 65 years old or greater, radiological studies with contrast, surgery and other procedures, hypoxic states, excessive alcohol intake, and hepatic impairment. If lactic acidosis is suspected, immediately discontinue metformin hydrochloride/sitagliptin phosphate and institute general supportive measures in a hospital setting; prompt hemodialysis is recommended . Uses for sitagliptin and metformin Metformin and sitagliptin combination is used to treat high blood sugar levels caused by type 2 diabetes. Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood. This medicine does not help patients w...

What is this medication? SITAGLIPTIN; METFORMIN (sit a GLIP tin; met FOR min) treats type 2 diabetes. It works by decreasing your blood sugar (glucose). Changes to diet and exercise are often combined with this medication. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. COMMON BRAND NAME(S): Janumet XR What should I tell my care team before I take this medication? They need to know if you have any of these conditions: • Anemia • Dehydration • Gallbladder disease • Heart disease • Heart failure • High levels of triglycerides in the blood • History of diabetic ketoacidosis • If you often drink alcohol • Kidney disease • Liver disease • Low levels of vitamin B12 in the blood • Pancreatitis • Polycystic ovary syndrome • Previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat • Serious infection or injury • Thyroid disease • Type 1 diabetes • An unusual or allergic reaction to metformin, sitagliptin, other medications, foods, dyes, or preservatives • Pregnant or trying to get pregnant • Breast-feeding How should I use this medication? Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Take this medication with food once daily in the evening. Do not cut, crush or chew this medication. Take your doses at regular intervals. Do not take your medication more often than directed. Do not sto...

Description and Brand Names Drug information provided by: US Brand Name • Janumet • Janumet XR Descriptions Metformin and sitagliptin combination is used to treat high blood sugar levels caused by type 2 diabetes. Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood. This medicine does not help patients who have insulin-dependent or type 1 diabetes. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: • Tablet, Extended Release • Tablet Before Using In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects ...

Usual Adult Dose for: • Additional dosage information: • • • • • • Usual Adult Dose for Diabetes Type 2 Dose should be individualized based on patient's current regimen, effectiveness, and tolerability. IMMEDIATE-RELEASE: • Initial dose for patients not receiving metformin: sitagliptin 50 mg/metformin 500 mg orally twice a day • Initial dose for patients receiving metformin: sitagliptin 50 mg in combination with half the daily dose of metformin orally twice a day (i.e, equal to same total daily dose of metformin currently being administered) EXTENDED-RELEASE: • Initial dose for patients not receiving metformin: sitagliptin 100 mg/metformin 1000 mg orally once a day • Initial dose for patients receiving metformin: sitagliptin 100 mg in combination with current daily metformin dose orally once a day TITRATE metformin dose slowly to reduce gastrointestinal side effects; titrate combination dose to achieve optimal glycemic control MAXIMUM: Sitagliptin 100 mg/day; Metformin 2000 mg/day Comments: • The same daily dose of metformin and sitagliptin should be maintained if need to change between immediate-release and extended-release products. • When initiating therapy, a dose adjustment of insulin secretagogue (e.g., sulfonylurea) or insulin may be necessary to reduce the risk of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. Renal Dose Adjustments Mild renal impairment (eGFR greater than 45 mL/min/1.73 ...

What is this medication? SITAGLIPTIN; METFORMIN (sit a GLIP tin; met FOR min) treats type 2 diabetes. It works by decreasing your blood sugar (glucose). Changes to diet and exercise are often combined with this medication. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. COMMON BRAND NAME(S): Janumet XR What should I tell my care team before I take this medication? They need to know if you have any of these conditions: • Anemia • Dehydration • Gallbladder disease • Heart disease • Heart failure • High levels of triglycerides in the blood • History of diabetic ketoacidosis • If you often drink alcohol • Kidney disease • Liver disease • Low levels of vitamin B12 in the blood • Pancreatitis • Polycystic ovary syndrome • Previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat • Serious infection or injury • Thyroid disease • Type 1 diabetes • An unusual or allergic reaction to metformin, sitagliptin, other medications, foods, dyes, or preservatives • Pregnant or trying to get pregnant • Breast-feeding How should I use this medication? Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Take this medication with food once daily in the evening. Do not cut, crush or chew this medication. Take your doses at regular intervals. Do not take your medication more often than directed. Do not sto...