Tamoxifen

Tamoxifen is a Tamoxifen is used to treat breast cancer in both premenopausal women (women who have not yet gone through the menopause) and postmenopausal women. It can also be taken by Some breast cancers use oestrogen in the body to help them to grow. These are known as oestrogen receptor positive or ER+ breast cancers. Tamoxifenblocks the effects of oestrogen on ER+ breast cancer cells. This stops oestrogen helping the breast cancer cells to grow. Find out more about Tamoxifen and coronavirus (Covid-19) Taking tamoxifen does not affect your risk of getting It’s also safe to have a Primary breast cancer Tamoxifen may be prescribed if you have It’s usually given after Occasionally, tamoxifen may be used as the first treatment for breast cancer. This may be when surgery is not appropriate or needs to be delayed. It’s sometimes given before surgery (known as neo-adjuvant or primary therapy) to shrink a larger breast cancer. For people diagnosed with an early type of breast cancer called Breast cancer that has come back or spread Tamoxifen can also be used to treat people who have: • • • To reduce the risk of breast cancer developing Tamoxifen may be an option for some people who do not have breast cancer but higher risk of developing it because of their Tamoxifen is taken as a tablet. Occasionally it may be prescribed as a liquid for people who have difficulty swallowing. The recommended dose for most people is 20mg daily. It’s best to take it at the same time every day. If...

(ta MOKS i fen) Trade names: ® Chemocare.com uses generic names in all descriptions of drugs. Nolvadex is the trade name for tamoxifen. In some cases, health care professionals may use the trade name Nolvadex when referring to the generic drug name tamoxifen. Drug type: Tamoxifen is a hormone therapy. This medication is classified as an "anti-estrogen" (for more detail, see "How this drug works" section below). What Tamoxifen Is Used For: • Tamoxifen may be given as adjuvant therapy (treatment after successful surgery) in women or men with lymph node negative or lymph node positive breast cancer. Cancers with positive estrogen and progesterone receptors are more likely to benefit from tamoxifen. Tamoxifen reduces the risk of getting breast cancer in the opposite breast. • Tamoxifen may be prescribed in metastatic (cancer that has spread) breast cancer in both women and men. • Tamoxifen may be prescribed in women with ductal carcinoma in situ (DCIS) who have completed surgery and radiation therapy. Tamoxifen may reduce the risk of invasive breast cancer. Risks and benefits of tamoxifen therapy should be discussed in this setting. • Tamoxifen may be prescribed for women at high risk of breast cancer to reduce the incidence of developing breast cancer. Risks and benefits of tamoxifen therapy should be discussed in this setting. • Tamoxifen may also be prescribed for treatment of ovarian cancer. Note: If a drug has been approved for one use, physicians may elect to use this sa...

WARNING For Women With Ductal Carcinoma in Situ (DCIS) and Women at High Risk for Breast Cancer Serious and life-threatening events associated with Tamoxifen in the risk reduction setting (women at high risk for cancer and women with DCIS) include uterine malignancies, stroke and pulmonary embolism. Incidence rates for these events were estimated from the NSABP P-1 trial (see Some of the strokes, pulmonary emboli, and uterine malignancies were fatal. Health care providers should discuss the potential benefits versus the potential risks of these serious events with women at high risk of breast cancer and women with DCIS considering Tamoxifen to reduce their risk of developing breast cancer. The benefits of Tamoxifen outweigh its risks in women already diagnosed with breast cancer. Updated long-term follow-up data (median length of follow-up is 6.9 years) from NSABP P-1 study. See See CLINICAL PHARMACOLOGY, Clinical Studies. Tamoxifen Description Tamoxifen citrate tablets USP, a nonsteroidal antiestrogen, are for oral administration. Each tablet contains 10 mg or 20 mg Tamoxifen (equivalent to 15.2 mg or 30.4 mg, respectively, of Tamoxifen citrate, USP). Each tablet contains the following inactive ingredients: croscarmellose sodium, hypromellose, lactose (monohydrate), magnesium stearate, polyethylene glycol 400, povidone, corn starch, and titanium dioxide. Chemically, Tamoxifen is the trans-isomer of a triphenylethylene derivative. The chemical name is (Z)2-[4-(1,2-diphenyl...

How it works Tamoxifen blocks the effects of estrogen — a reproductive hormone that influences the growth and development of many breast cancers. Tamoxifen belongs to a class of drugs known as selective estrogen receptor modulators (SERMs). The drug reduces the effects of estrogen in most areas of the body, including the breast. In the uterus, however, tamoxifen acts like an estrogen and encourages the growth of the lining of the uterus. Tamoxifen is usually prescribed as a pill taken once a day by mouth. For breast cancer risk reduction, tamoxifen is typically taken for a total of five years. The risk reduction benefit continues for five additional years after you stop taking tamoxifen. In total, you could receive up to 10 years of benefit. Who it's for Tamoxifen is used to reduce the risk of invasive breast cancer if you're at high risk and you're 35 and older, whether or not you've gone through menopause. You and your health care provider might consider whether chemoprevention with tamoxifen is right for you if: • Your Gail model risk score is greater than 1.7%. The Gail model is a tool that health care providers use to predict future risk of developing breast cancer. The risk score is based on factors such as age, reproductive history and family history. • You're at high risk of developing breast cancer. For instance, you've had a breast biopsy that found a precancerous condition such as lobular carcinoma in situ, atypical ductal hyperplasia or atypical lobular hyperpl...

Warning • This medicine may raise the chance of very bad and sometimes deadly side effects like stroke, blood clots, or endometrial or uterine cancer. Uses of Tamoxifen Tablets: • It is used to treat • It is used to lower the chance of breast • It may be given to you for other reasons. Talk with the doctor. Related/similar drugs What do I need to tell my doctor BEFORE I take Tamoxifen Tablets? • If you have an allergy to • If you are allergic to this medicine (tamoxifen tablets); any part of this medicine (tamoxifen tablets); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. • If you have blood clots or have had blood clots in the past. • If you are taking any of these drugs: • If you are taking any of these drugs: • If you are breast-feeding. Do not breast-feed while you take this medicine (tamoxifen tablets) or for 3 months after your last dose. This is not a list of all drugs or health problems that interact with this medicine (tamoxifen tablets). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, What are some things I need to know or do while I take Tamoxifen Tablets? • Tell all of your health care providers that you take this medicine (tamoxifen tablets). This includes your doctors, nurses, pharmacists, and dentists. • Have blood work checked as you have been told by the doctor. Talk with the doctor. • This medicine may affect certain lab tests. Tell all of your health car...