Thrombocytopenia icd 10

Multiple causes (pseudothrombocytopenia, hemodilution, increased consumption, decreased production, increased sequestration, and immune-mediated destruction of platelets) alone or in combination make thrombocytopenia very common in intensive care unit (ICU) patients. Persisting thrombocytopenia in critically ill patients is associated with, but not causative of, increased mortality. Identification of the underlying cause is key for management decisions in individual patients. While platelet transfusion might be indicated in patients with impaired platelet production or increased platelet destruction, it could be deleterious in patients with increased intravascular platelet activation. Sepsis and trauma are the most common causes of thrombocytopenia in the ICU. In these patients, treatment of the underlying disease will also increase platelet counts. Heparin-induced thrombocytopenia requires alternative anticoagulation at a therapeutic dose and immune thrombocytopenia immunomodulatory treatment. Thrombocytopenia with symptomatic bleeding at or above World Health Organization grade 2 or planned invasive procedures are established indications for platelet transfusions, while the evidence for a benefit of prophylactic platelet transfusions is weak and controversial. If the platelet count does not increase after transfusion of 2 fresh ABO blood group–identical platelet concentrates (therapeutic units), ongoing platelet consumption and high-titer anti-HLA class I antibodies shou...

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Increased splenic platelet sequestration can occur in various disorders that cause Splenomegaly Splenomegaly is abnormal enlargement of the spleen. (See also Overview of the Spleen.) Splenomegaly is almost always secondary to other disorders. Causes of splenomegaly are myriad, as are the... read more . However, thrombocytopenia that occurs in advanced Cirrhosis Cirrhosis is a late stage of hepatic fibrosis that has resulted in widespread distortion of normal hepatic architecture. Cirrhosis is characterized by regenerative nodules surrounded by dense... read more is mostly due to reduced thrombopoietin production by the liver (and consequent reduced platelet production) rather than splenic sequestration ( General reference Increased splenic platelet sequestration can occur in various disorders that cause splenomegaly. However, thrombocytopenia that occurs in advanced cirrhosis is mostly due to reduced thrombopoietin... read more ). (See also Overview of Platelet Disorders Platelets are circulating cell fragments that function in the clotting system. Thrombopoietin helps control the number of circulating platelets by stimulating the bone marrow to produce megakaryocytes... read more .)

Overview Thrombocytopenia is a condition in which you have a low blood platelet count. Platelets (thrombocytes) are colorless blood cells that help blood clot. Platelets stop bleeding by clumping and forming plugs in blood vessel injuries. Thrombocytopenia might occur as a result of a bone marrow disorder such as leukemia or an immune system problem. Or it can be a side effect of taking certain medications. It affects both children and adults. Petechiae Bleeding into the skin looks like tiny reddish-purple spots, also known as petechiae. Petechiae might look like a rash. Here they appear on a leg (A) and on the stomach area (B). Thrombocytopenia signs and symptoms may include: • Easy or excessive bruising (purpura) • Superficial bleeding into the skin that appears as a rash of pinpoint-sized reddish-purple spots (petechiae), usually on the lower legs • Prolonged bleeding from cuts • Bleeding from your gums or nose • Blood in urine or stools • Unusually heavy menstrual flows • Fatigue • Enlarged spleen When to see a doctor Make an appointment with your doctor if you have signs of thrombocytopenia that worry you. Bleeding that won't stop is a medical emergency. Seek immediate help for bleeding that can't be controlled by the usual first-aid techniques, such as applying pressure to the area. Enlarged spleen The spleen is a small organ usually about the size of your fist. But a number of conditions, including liver disease and some cancers, can cause your spleen to become enla...

Thrombocytopenia is the name for a low platelet count. Platelets are blood cells that help the blood clot. The two main factors that cause low platelet counts are medication side effects and underlying health conditions. A reduced platelet count in the blood is not always a serious problem. However, the condition affects the ability of the blood to clot. If a person’s blood does not clot, a wound This article examines the conditions, medications, and substances that can cause a low platelet count. It also outlines how to recognize the symptoms and what to expect from treatment. Share on Pinterest Ed Reschke/Yoshiyoshi Hirokawa/Getty Images Thrombocytopenia is a condition that occurs when the platelet count in a person’s blood is too low. The normal platelet count in adults is 150,000–450,000 platelets per microliter (µl) of blood. A person with thrombocytopenia will have a platelet count below 150,000/ µl. Thrombocytopenia may make it difficult for the body to stop bleeding following an injury. Bleeding can occur inside the body, beneath the skin, or at the surface of the skin. People with thrombocytopenia usually do not experience serious bleeding until their platelet count is very low. There are Medical conditions that can cause a low platelet count A low platelet count may occur due to : • the bone marrow not producing enough platelets • the body destroying or using up the platelets that the bone marrow does produce • the spleen holding onto too many platelets, meaning ...