Which of the following plant is used to extract colchicine

The correct answer is ​Colchicum autumnale. Key Points • Colchicine, a mitotic poison, is obtained from a plant, Colchicum autumnale. This plant is commonly known as autumn crocus, meadow saffron. • The seed, bulb, and flower are used to make medicine. The appropriate dose of autumn crocus depends on several factors such as the user's age, health, and several other conditions. • All parts of autumn crocuses are poisonous, with the greatest concentrations of toxic alkaloids occurring in the flowers and seeds. The primary toxic alkaloid is colchicine, which interferes with cell mitosis. • Colchicine and its related alkaloids interfere with microtubular-dependent cell functions by binding to tubulin protein, thus blocking mitosis in multiple tissues. All animals are susceptible to the toxic effects of colchicine. • The swollen underground stem of the autumn crocus plant is used to treat the pain caused by gout and Mediterranean fever. • Clinical trials in many countries showed good results in the treatment of COVID-19 patients using medicines named "COLCORONA" showed encouraging results. Additional Information • Pyrethrum: • ​Pyrethrum is the crude extract form obtained from flowers of the plant Chrysanthemum cinerariifolium. • Pyrethrin refers to a more refined extract of pyrethrum. • While pyrethrum extract is composed of 6 esters, both organic compounds mediate insecticidal activities. • Pyrethrum-containing mixtures are used as a common insecticide to control specific pes...

Colchicum Extract Colchicine, the main active ingredient in Colchicum Extract, is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (Autumn crocus, Colchicum autumnale, also known as the "Meadow saffron"). Product Name: Colchicum extract Ingredient: Colchicine 98% tested by HPLC Appearance:Yellow fine powder 100% through 80 Mesh Package: 1-5kg Aluminum Foil Bag;10kg or 25kg Paper Drum Shelf Life: 2 Years Information of Colchicum Extract Clinical application--Colchicine is mainly used in treatment of breast cancer, lung cancer, stomach cancer, skin cancer and chronic myelogenous leukemia, but can also be used to relieve acute attack of gout. Application of Colchicum Extract 1. Applied in health food 2. Applied in pharmaceuticals

In this research an ultrasound-assisted extraction (UAE) method was used for extraction of colchicine in root of Colchicum haussknechtii prior to high-performance liquid chromatography with UV detection. C. haussknechtii is used widely in traditional medicine for the treatment of various diseases. The root of this plant is full of colchicine that is suitable for the treatment of gout and cirrhosis and applicable in plant breeding studies to produce polyploidy. The influence of variables on the extraction method was investigated by response surface methodology (RSM) and composite design (CCD) to achieve maximum extraction yield of colchicine from the root of C. haussknechtii. The most suitable condition for the extraction of colchicine was found to at 40°C temperature, 32min extraction time, and 70:30 v/v ethanol–water mixtures with 45:1 solvent-solid ratio. Obtained results showed that there is 1.2% colchicine in the root of C. haussknechtii, so this plant could be introduced as a rich source of colchicine. • Previous article in issue • Next article in issue

Few complete pathways have been established for the biosynthesis of medicinal compounds from plants. Accordingly, many plant-derived therapeutics are isolated directly from medicinal plants or plant cell culture Colchicum and Gloriosa species Gloriosa superba for the biosynthesis of N-formyldemecolcine, a colchicine precursor that contains the characteristic tropolone ring and pharmacophore of colchicine N-formyldemecolcine in Nicotiana benthamiana starting from the amino acids phenylalanine and tyrosine. This study establishes a metabolic route to tropolone-containing colchicine alkaloids and provides insights into the unique chemistry that plants use to generate complex, bioactive metabolites from simple amino acids. Open Access articles citing this article. • • Jianing Han • & Sijin Li Communications Chemistry Open Access 09 February 2023 • • Zheng Zhuang • , Xueqing Zhong • … Wen Liu Bioresources and Bioprocessing Open Access 09 January 2023 • • Jing Wang • , Jingjing Xie • … Binbin Wang Communications Biology Open Access 25 November 2022 Access options All reported data in this study are available via database or by request from the corresponding author. Coding DNA sequences for the genes characterized and assessed in this study are provided as FASTA sequences in the OMT1 ( NMT ( NMTt ( CYP75A109 ( OMT2 ( OMT3 ( CYP75A110 ( OMT4 ( CYP71FB1 ( TyDC/DDC ( PAL ( CCR ( AER ( 4CL ( C4H ( DAHPS ( NCS ( NCS ( G. superba are deposited in the NCBI Sequence Read Archive (SRA) da...