Deflazacort tablet

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Description and Brand Names Drug information provided by: US Brand Name • Emflaza Descriptions Deflazacort is used to treat Duchenne muscular dystrophy (DMD). DMD is a rare, inherited muscle disease that occurs usually in children and young adults and is caused by an absence of a protein called dystrophin, which helps keep muscle cells intact. Deflazacort is corticosteroid (cortisone-like medicine or steroid). This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: • Tablet • Suspension • Portions of this document last updated: May 01, 2023 Copyright: © Merative US L.P. 1973, 2023. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. • •

Deflazacort belongs to a class of medicines known as corticosteroids (more commonly called steroids). Your pharmacist will give you a blue 'Steroid Treatment Card'. Carry this with you at all times. Take deflazacort with a drink of water at breakfast. If you need any medical treatment, make sure the person treating you knows you are taking deflazacort. This is because your dose may need to be increased for a short while. Type of medicine A corticosteroid medicine Used for Allergic and inflammatory conditions in adults or children Also called Calcort® Available as Tablets Deflazacort belongs to a group of medicines called corticosteroids. It is sometimes referred to simply as an Corticosteroids like deflazacort are used to treat a wide variety of conditions. Some examples include autoimmune diseases (for example, Deflazacort works by interfering with the release of certain chemicals in your body which cause inflammation. Before taking deflazacort Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking deflazacort it is important that your doctor knows: • If you have high blood pressure. • If you have had a heart attack, or if you have any other heart problems. • If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work. • If you (or a close family member) have either diabetes or an eye condition cal...

Deflazacort Tablets Generic name: Deflazacort Tablets [ de-FLAZE-a-kort] Brand name: Drug class: • • • • • • • Uses of Deflazacort Tablets: • It is used to treat What do I need to tell my doctor BEFORE I take Deflazacort Tablets? • If you are allergic to this medicine ( • If you have an • If you have any of these health problems: • If you have recently had stomach or bowel • If you take any drugs (prescription or OTC, natural products, This is not a list of all drugs or health problems that interact with this medicine (deflazacort tablets). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (deflazacort tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. What are some things I need to know or do while I take Deflazacort Tablets? • Tell all of your health care providers that you take this medicine (deflazacort tablets). This includes your doctors, nurses, pharmacists, and dentists. • Have blood work checked as you have been told by the doctor. Talk with the doctor. • You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly. • Call your doctor right away if you have any signs of infection like • Chickenpox and • Very bad an...

Deflazacort is a corticosteroid medication that treats Duchenne muscular dystrophy. This condition causes skeletal and heart muscle weakness that quickly gets worse with time. You can take this tablet by mouth as directed by either swallowing the tablets whole or crushing them and adding the tablets into soft, wet food. What is this medication? Deflazacort (de FLAZ a kort) is a corticosteroid. This medicine is used for the treatment of Duchenne muscular dystrophy. It is not a cure. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. COMMON BRAND NAME(S): Emflaza What should I tell my care team before I take this medication? They need to know if you have any of these conditions: • Cushing's syndrome • diabetes • glaucoma • heart problems or disease • high blood pressure • infection such as herpes, measles, or chickenpox • kidney disease • liver disease • mental problems • myasthenia gravis • osteoporosis • seizures • stomach ulcer or intestine disease including colitis and diverticulitis • thyroid problem • an unusual or allergic reaction to deflazacort, other medicines, foods, dyes, or preservatives • pregnant or trying to get pregnant • breast-feeding How should I use this medication? Take this medicine by mouth. You can crush and mix it with applesauce or swallow the tablets whole. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take it more often than directed. ...

Further information: Deflazacort is an inactive Relative potency [ ] Deflazacort's potency is around 70–90% that of History [ ] In January 2015, the FDA granted Deflazacort is sold in the United States under the brand name Emflaza after PTC Therapeutics, Inc. acquired all rights to Emflaza on March 16, 2017. The U.S. Food and Drug Administration approved deflazacort to treat people age five years and older with Duchenne muscular dystrophy (DMD), a rare genetic disorder that causes progressive muscle deterioration and weakness. Emflaza is a corticosteroid that works by decreasing inflammation and reducing the activity of the immune system. References [ ] • Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p.486. 9783527607495. • (PDF). U.S. . Retrieved 16 September 2020. • (PDF). • ^ a b U.S. Food and Drug Administration (Press release) . Retrieved 18 February 2017. This article incorporates text from this source, which is in the . • DailyMed. 29 January 2020 . Retrieved 17 September 2020. • Möllmann H, Hochhaus G, Rohatagi S, Barth J, Derendorf H (July 1995). "Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone". Pharmaceutical Research. 12 (7): 1096–100. • ^ a b Retrieved on October 28, 2008. • Parente L (January 2017). BMC Pharmacology & Toxicology. 18 (1): 1. • Hirst EJ (January 19, 2015), Duchenne muscular dystrophy drug could get OK for U.S. sales in 2016, The Chicago Tribune , r...

Before taking this medicine You should not use deflazacort if you are allergic to it. Deflazacort should not be given to a child younger than 2 years old. Deflazacort oral suspension (liquid) contains an ingredient that can cause serious side effects or death in very young or premature babies. Tell your doctor if you have ever had: • any type of bacterial, fungal, viral, or parasite • heart problems, • a stroke or blood clot; • • kidney disease; • liver disease (especially • a stomach or intestinal disorder; • a • cataracts, • diabetes; • a nerve-muscle disorder, such as • low bone mineral density; or • a problem with your thyroid, pituitary gland, or adrenal gland. You should be current on all vaccines. Tell your doctor if you have recently received a vaccine or if you are scheduled for a booster dose. Long-term use of steroids may lead to bone loss ( Taking deflazacort during early pregnancy may increase the risk of cleft lip and palate in a newborn. Tell your doctor if you are pregnant or plan to become pregnant. Taking deflazacort at any time during pregnancy may affect adrenal gland It may not be safe to breastfeed while using deflazacort. Ask your doctor about any risk. How should I take deflazacort? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take deflazacort with or without food. You may need to take multiple tablet...

What Are Dosages of Deflazacort? Dosages of Deflazacort: Dosage Forms and Strengths Tablet • 6 mg • 18 mg • 30 mg • 36 mg Oral Suspension • 22.75 mg/mL Dosage Considerations – Should be Given as Follows: Duchenne Muscular Dystrophy • Indicated for Duchenne • Adults and children 2 years and older: 0.9 mg/kg/day orally once daily • Children under 2 years: Safety and efficacy not established • If tablets are used, round up to the nearest possible dose; may use any combination of tablet strengths to achieve calculated dose • If the oral suspension is used, round up to the nearest tenth of a milliliter (mL) • When discontinuing treatment, gradually decrease the dose is administered for more than a few days • If tablets are used, round up to the nearest possible dose; may use any combination of tablet strengths to achieve calculated dose • If the oral suspension is used, round up to the nearest tenth of a milliliter (mL) • When discontinuing treatment, gradually decrease the dose is administered for more than a few days Dosage Modifications Coadministration with CYP3A4 inhibitors • Moderate or strong CYP3A4 inhibitors: Give one third the recommended deflazacort dose • Example: Reduce a 36-mg/day dose to 12 mg/day when used with moderate or strong CYP3A4 inhibitors Coadministration with CYP3A4 inducers • Moderate or strong CYP3A4 inducers: Avoid use Renal impairment • Mild, moderate, or severe: No dose adjustment is required Hepatic impairment • Mild or moderate: No dose adjustme...

This medicine should come with patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions. You may take this medicine with or without food. You may swallow the tablet whole. You may also crush and mix it with applesauce. Take the mixture right away. Shake well the oral suspension before each use. Measure the dose with the oral dispenser that comes with it. Add your dose with 3 or 4 ounces of juice or milk, mix well, and take it right away. Do not drink grapefruit juice while you are using this medicine. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. • For oral dosage form (suspension and tablets): • For treatment of Duchenne muscular dystrophy • Adults and children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 0.9 milligram (mg) per kilogram (kg) of body weight once a day. • Children younger than 2 years of age—Use and dose must be determined by your doc...

Description and Brand Names Drug information provided by: US Brand Name • Emflaza Descriptions Deflazacort is used to treat Duchenne muscular dystrophy (DMD). DMD is a rare, inherited muscle disease that occurs usually in children and young adults and is caused by an absence of a protein called dystrophin, which helps keep muscle cells intact. Deflazacort is corticosteroid (cortisone-like medicine or steroid). This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: • Tablet • Suspension • Portions of this document last updated: May 01, 2023 Copyright: © Merative US L.P. 1973, 2023. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. • •