Ondansetron orally disintegrating tablets ip 4mg uses in hindi

Ondansetron (Monograph) Brand name: Drug class: 5-HT3 Receptor Antagonists VA class: GA700 Chemical name: 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one monohydrochloride dihydrate Molecular formula: C 18H 19N 3O•ClH• 2H 2O CAS number: 103639-04-9 • • • • • • • Introduction Antiemetic; selective, first-generation inhibitor of type 3 serotonergic (5-HT 3) receptors. Uses for Ondansetron Cancer Chemotherapy-induced Nausea and Vomiting Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy; may use orally with highly emetogenic chemotherapy (i.e., cisplatin ≥50 mg/m 2) or initial and repeat courses of moderately emetogenic chemotherapy, or IV with initial and repeat courses of emetogenic chemotherapy, including high-dose cisplatin. For prevention of nausea and vomiting associated with highly emetogenic chemotherapy regimens (including an anthracycline plus cyclophosphamide), ASCO recommends a 3-drug antiemetic regimen consisting of an NK 1 receptor antagonist (e.g., either oral aprepitant or IV fosaprepitant), a 5-HT 3 receptor antagonist (e.g., dolasetron, granisetron, ondansetron, palonosetron), and dexamethasone. ASCO states that fixed-combination netupitant and palonosetron plus dexamethasone is an additional treatment option. For moderately emetogenic chemotherapy regimens, ASCO recommends a 2-drug antiemetic regimen preferably consisting of palonosetron and dexamethasone. If palonosetron is not available, a ...