Where will you find more number of ribosomes in cancer cells or in fat cells

The ribosome has long been considered as a consistent molecular factory, with a rather passive role in the translation process. Recent findings have shifted this obsolete view, revealing a remarkably complex and multifaceted machinery whose role is to orchestrate spatiotemporal control of gene expression. Ribosome specialization discovery has raised the interesting possibility of the existence of its malignant counterpart, an 'oncogenic' ribosome, which may promote tumor progression. Here we weigh the arguments supporting the existence of an 'oncogenic' ribosome and evaluate its role in cancer evolution. In particular, we provide an analysis and perspective on how the ribosome may play a critical role in the acquisition and maintenance of cancer stem cell phenotype. Accumulating evidence suggests that, far from being a consistent molecular factory, the ribosome may, in fact, be a critical variable in gene expression control. The existence of 'specialized ribosomes', characterized by unique composition and specific functions, is now solidifying The purpose of this review is to summarize and discuss the role of ribosome in cancer etiology and progression in the light of recent developments in ribosome biology. We start by providing a brief overview of current knowledge on mammalian ribosome, from its biogenesis to its essential role in fine-tuning gene expression. Then, we put forward arguments supporting the involvement of altered ribosome components in neoplastic process. ...

Liposarcoma Liposarcoma is a type of cancer that starts in the fat cells. It happens most often in the muscles of the limbs or the abdomen. Liposarcoma is a rare type of cancer that starts in the fat cells. It most often begins as a growth of cells in the belly or in the arm and leg muscles. But liposarcoma can begin in the fat cells anywhere in the body. Liposarcoma happens most often in older adults, but it can happen at any age. Symptoms Liposarcoma symptoms depend on the part of the body where the cancer forms. Liposarcoma in the arms and legs can cause: • A growing lump of tissue under the skin. • Pain. • Swelling. • Weakness of the affected limb. Liposarcoma in the belly, also called the abdomen, can cause: • Abdominal pain. • Abdominal swelling. • Feeling full sooner when eating. • Constipation. • Blood in stool. When to see a doctor Make an appointment with a doctor or other health care professional if you have any symptoms that don't go away and that worry you. There is a problem with information submitted for this request. Review/update the information highlighted below and resubmit the form. Get Mayo Clinic cancer expertise delivered to your inbox. Subscribe for free and receive an in-depth guide to coping with cancer, plus helpful information on how to get a second opinion. You can unsubscribe at any time. I would like to learn more about Causes It's not clear what causes liposarcoma. Liposarcoma starts when fat cells get changes in their DNA. A cell's DNA hold...

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