Rabeprazole

Type of medicine Proton pump inhibitor Used for Gastric and duodenal ulcers; gastro-oesophageal reflux disease; Helicobacter pylori infection; Zollinger-Ellison syndrome Also called Pariet® Available as Tablets Acid is produced naturally in your stomach to help you digest food and to kill germs (bacteria). This acid is irritant so your body produces a natural mucous barrier which protects the lining of your stomach. In some people, this barrier can break down allowing the acid to damage the stomach, causing inflammation, ulcers and other conditions. Other people can have a problem with the muscular band at the top of the stomach that keeps the stomach tightly closed. This may allow the acid to escape and irritate the oesophagus, causing heartburn. This is often referred to as 'acid reflux'. Rabeprazole is also used as one part of a treatment to get rid of Helicobacter pylori, a bacterium found in the stomach, which can cause ulcers. Before taking rabeprazole Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking rabeprazole it is important that your doctor knows: • If you are pregnant, trying for a baby or breastfeeding. • If you have any of the following symptoms: difficulty swallowing, loss of blood, weight loss, or if you are being sick. • If you have any problems with the way your liver works. • If you have weakened bones due to osteoporosis or you ...

What Is Aciphex? Aciphex (rabeprazole sodium) is a proton pump inhibitor (PPI) to reduce stomach acid and is used for the treatment of What Are Side Effects of Aciphex? Common side effects of Aciphex may include: • rash or itching, • upset stomach, • diarrhea, • gas, • • headache, • insomnia, or • nervousness. Serious side effects of Aciphex include: • • abnormal brain function or structure ( • dizziness, • swelling, • joint pain, and • muscle pains. Dosage for Aciphex Aciphex is available in 20 mg strength What Drugs, Substances, or Supplements Interact with Aciphex? Aciphex may interact with atazanavir, blood thinners, digoxin, Aciphex During Pregnancy and Breastfeeding Pregnant women and their doctors need to balance the need vs the potential problems of Aciphex in pregnancy and breastfeeding. Aciphex has been used in pediatric patients, aged 12 and above for GERD treatment; no studies under age 12 are available. Additional Information Our Aciphex Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Find Lowest Prices on /b> DESCRIPTION The active ingredient in ACIPHEX delayed-release tablets is rabeprazole sodium, which is a proton pump inhibitor. It is a substituted benzimidazole known chemically as 2-[[[4-(3methoxypropoxy)-3-methyl-2-pyridinyl]-methyl]sulfinyl]-1H–benzimidazole sodium salt. It has an empirical formula of C 18H 20N 3NaO 3S and a molecular weight of 381.42. Rabep...

Aciphex, Pariet Generic Name Rabeprazole DrugBank Accession Number DB01129 Background Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. Type Small Molecule Groups Approved, Investigational Structure Learn more Pharmacodynamics Rabeprazole prevents the production of acid in the stomach. It reduces symptoms and prevents injury to the esophagus or stomach in patients with gastroesophageal reflux disease (GERD) or ulcers. Rabeprazole is also useful in conditions that produce too much stomach acid such as Zollinger-Ellison syndrome. Rabeprazole may also be used with antibiotics to get rid of bacteria that are associated with some ulcers. Rabeprazole is a selective and irreversible proton pump inhibitor, suppresses gastric acid secretion by specific inhibition of the H +, K + -ATPase, which is found at the secretory surface of parietal cells. In doing so, it inhibits the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen. Mechanism of action Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibit...

Dosages of Rabeprazole Dosage Forms and Strengths Tablet, delayed-release • 20 mg Capsule, sprinkle • 5 mg • 10 mg Dosage Considerations – Should be Given as Follows: sprinkle • Indicated for short-term (up to 4 weeks) treatment in healing and symptomatic relief of duodenal ulcers • 20 mg orally once/day after morning meal for up to 4 weeks; to achieve healing, some patients may require additional therapy Helicobacter Pylori Eradication • In combination with H. pylori infection and • 20 mg orally twice daily for 7 days with morning and evening meals; take with amoxicillin 1000 mg orally twice daily and clarithromycin 500 mg twice daily Adult: Healing or erosive or ulcerative GERD • 20 mg orally once/day for 4-8 weeks; if not healed after 8 weeks, an additional 8-week course may be considered • Maintenance dosing (20 mg/day for up to 12 months) shown to reduce relapse rates Symptomatic GERD • Treatment of daytime and nighttime heartburn and other symptoms associated with GERD • 20 mg orally once/day for 4 weeks; if symptoms not completely resolved after 4 weeks, an additional course may be considered Pediatric: Delayed-release tablet • Indicated for short-term treatment of symptomatic GERD in adolescents • Children 12 years and older: 20 mg orally once/day for up to 8 weeks • Children under 12 years: Safety and efficacy not established Delayed-release capsule (sprinkles) • Children 1-12 years (less than 15 kg): 5 mg orally once/day 30 minutes before a meal, for up to 12 wee...

Dosage Forms & Strengths tablet, delayed-release • 20mg Duodenal Ulcer Indicated for short-term (up to 4 weeks) treatment in healing and symptomatic relief of duodenal ulcers 20 mg PO qDay after morning meal for up to 4 weeks; to achieve healing, some patients may require additional therapy Helicobacter Pylori Eradication In combination with amoxicillin and clarithromycin for treatment of H pylori infection and duodenal ulcer disease (active or history within past 5 yr) 20 mg PO BID for 7 days with morning and evening meals; take with amoxicillin 1000 mg PO BID and clarithromycin 500 mg BID Gastroesophageal Reflux Disease Healing or erosive or ulcerative GERD • 20 mg PO qDay for 4-8 weeks; if not healed after 8 weeks, an additional 8-week course may be considered • Maintenance dosing (20 mg/day for up to 12 months) shown to reduce relapse rates Symptomatic GERD • Treatment of daytime and nighttime heartburn and other symptoms associated with GERD • 20 mg PO qDay for 4 weeks; if symptoms not completely resolved after 4 weeks, an additional course may be considered Hypersecretory Conditions Long-term treatment of pathologic hypersecretory conditions, including Zollinger-Ellison syndrome 60 mg PO qDay initially; may increase to 100 mg PO qDay or 60 mg PO q12hr Dosing considerations • Continue use as long as clinically needed; some patients with SE have been treated continuously for up to 1 yr Dosage Modifications Renal impairment: Dose adjustment not necessary Hepatic impairm...